Panty and Stocking, Anarchy sisters are angels who were expelled from heaven because of their bad behavior. Are sent to Daten City, a place located somewhere between Heaven and Hell. Strange monsters called "Ghosts" begin to terrorize the place, but under the watchful eye of Reverend Garterbelt, it is up to Panty and Stocking destroy these Ghosts, and in doing so receive Heavens which will allow them to return to heaven when they have enough.
two fallen angels have very different things in mind than to pursue this activity. Panty nibbled instead a lover after another, and is not picky as long as she gets her orgasm. Stocking, however, has little interest in men, devoted to prefer the consumption of sweets of all kinds and dresses like a Gothic Lolita.